Cancer-Specific Survival after Limb Salvage versus Amputation in Children and Adolescents with Osteosarcoma: A Population-Based Analysis with Propensity Score Matching

Table 3

Univariate and multivariate Cox regression analysis for OS in the matched cohort.

Characteristics	The univariate			The multivariate
	HR	CI.x	value	HR.y	CI.y	value
Age
<15	Reference
15–39	1.25	0.95–1.64	0.111
Chemotherapy
No/unknown	Reference
Yes	1.52	0.78–2.96	0.219
Histology
Conventional	Reference			Reference
Others	0.58	0.37–0.92	0.020	0.63	0.4–1.01	0.055
Primary site
Upper	Reference
Lower	0.73	0.52–1.02	0.063
Pelvic	1.55	0.88–2.75	0.132
Race
White	Reference			Reference
Black	1.47	1.01–2.13	0.045	1.22	0.84–1.78	0.302
Others	0.93	0.61–1.42	0.748	1.06	0.69–1.61	0.799
Sex
Female	Reference
Male	1.14	0.86–1.5	0.368
Stage
I	Reference			Reference
II	1.52	0.7–3.28	0.291	1.27	0.58–2.78	0.5511
III	5.78	2.15–15.51	0.001	5.26	1.95–14.18	0.001
IV	6.23	2.91–13.33	<0.001	5.54	2.56–12.01	<0.001
Surgery
Amputation	Reference			Reference
LSS	0.69	0.52–0.91	0.009	0.58	0.44–0.77	<0.001