Microdissecting the Hypoxia Landscape in Colon Cancer Reveals Three Distinct Subtypes and Their Potential Mechanism to Facilitate the Development of Cancer

Figure 1

Microdissection of the hypoxia landscape in TCGA-COAD cohort and GSE17538 cohort. Consensus matrix plot of unsupervised clustering in TCGA-COAD cohort (a) and GSE17538 cohort (b), when k = 3 representing the optimal cluster number. (c) and (g) PCA plot of hypoxia-specific clusters. Comparison of HIF1A expression (d) and (h), HALLMARK_HYPOXIA pathway score (e) and (i), and the survival difference (f) and (j) among hypoxia-specific clusters. COAD: colon adenocarcinoma. PCA: principal component analysis. Hypoxia-L: hypoxia-low; hypoxia-M: hypoxia-median; hypoxia-H: hypoxia-high. OS: overall survival.

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