Microdissecting the Hypoxia Landscape in Colon Cancer Reveals Three Distinct Subtypes and Their Potential Mechanism to Facilitate the Development of Cancer

Figure 6

The distinct immune infiltration patterns in TCGA-COAD cohort. Comparison of the immune infiltration level (a), immune pathway activity (b), and immune checkpoint expression level (c) between HRI high-risk and low-risk groups. Comparison of TIDE scores between HRI high-risk and low-risk groups in TCGA-COAD (d). Correlation between TIDE scores and HRI scores in TCGA-COAD (e). Comparison of responder proportion predicted by the TIDE algorithm in TCGA-COAD (f). TIDE: tumor immune dysfunction and exclusion. HRI: hypoxia-related index.  < 0.001;  < 0.01;  < 0.05; ns, no significance.

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