Journal of Obesity

Research Article

Altered Left Ventricular Ion Channel Transcriptome in a High-Fat-Fed Rat Model of Obesity: Insight into Obesity-Induced Arrhythmogenesis

Table 2

Simulated changes in current density based on the mRNA expression differences shown in Figures 1–3.
ChannelCurrentHigh fat
1.5 +163.60%
1.2 +441.28%
1.4, 4.2, and 4.3+240.45%
1.5+232.73%
HCN4+222%
2.1 +233.83%
NCX1+290.10%
SERCA2aSR Ca2+ uptake+139%
RYR2SR Ca2+ release+253.97%
ATP1α1-3251%