Using Adipose Measures from Health Care Provider-Based Imaging Data for Discovery

Figure 5

The plot shows −log( values) for top sex-stratified phenotypic associations of ICD-9-based diagnoses with VAT on the y-axis after controlling for age. (a) Top female phenotypic associations of ICD-9 codes with VAT. Point size refers to the number of cases (250, 500, and 750). (b) Odds ratios and 95% CIs of top female phenotypic associations of ICD-9 codes with VAT after controlling for age. (c) Top male phenotypic associations of ICD-9 codes with VAT. Point size refers to the number of cases (100, 200, and 300). (d) Odds ratios and 95% CIs of top male phenotypic associations of ICD-9 codes with VAT after controlling for age. In all panels, females are represented in purple and males in green. The direction of the point, upwards or downwards, represents the direction of the corresponding beta estimate (positive or negative). The red line corresponds to the Bonferroni threshold, whereas the green line corresponds to the 1% FDR threshold.

(a)

(b)

(c)

(d)