Therapeutic Effect of P-Cymene on Lipid Profile, Liver Enzyme, and Akt/Mtor Pathway in Streptozotocin-Induced Diabetes Mellitus in Wistar Rats

Table 2

Results of the AST, ALT, ALP, and MDA in diabetes rats and controls.

Group	AST (mg/dl)	ALT (mg/dl)	ALP (mg/dl)	MDA (μmol/l)
Control (C)	81.50 ± 2.53^###	66.17 ± 4.10^###	473.80 ± 26.11^###	5.17 ± 0.40^###
Sham (D)	110.67 ± 1.48^+++	97.17 ± 1.17^+++	1007.50 ± 16.01^+++	10.17 ± 0.48^+++
Met	92.00 ± 2.83^###	57.00 ± 2.84^###	391.67 ± 14.40^###	5.25 ± 0.48^###
C25	95.25 ± 1.28^###	65.33 ± 3.38^###	777.75 ± 29.58^##+++	5.83 ± 0.31^###
C50	92.17 ± 2.77^###	72.83 ± 4.73^###	741.20 ± 27.94^###+++	5.33 ± 0.21^###
C100	91.33 ± 2.09^###	56.50 ± 4.51^###	730.50 ± 36.38^###+++	5.00 ± 0.37^###
D25	87.00 ± 2.32^###	66.00 ± 6.52^###	500.33 ± 52.85^###	6.67 ± 0.33^###
D50	94.50 ± 1.80^###	59.00 ± 2.00^###	457.50 ± 48.08^###	7.00 ± 0.37^###+
D100	102.33 ± 2.08^+	58.83 ± 1.14^###	523.20 ± 33.68^###	6.63 ± 0.33^###

Values are presented as mean ± SEM (n = 6/each group). Statistically different from the control rats (), statistically different from the control rats (); ^##statistically different from the sham rats (), ^###statistically different from the sham rats (); ⁺Statistically different from the Met rats (), ⁺⁺⁺statistically different from the Met rats (). The sham (D): diabetic rats, MET: diabetic rats + metformin (55 mg/kg), C25: control rats + p-cymene (25 mg/kg), C50: control rats + p-cymene (50 mg/kg), C100: control rats + p-cymene (100 mg/kg), D25: diabetic rats + p-cymene (25 mg/kg), D50: diabetic rats + p-cymene (50 mg/kg), D100: diabetic rats + p-cymene (100 mg/kg). AST: aspartate aminotransferase, ALT: alanine aminotransferase, ALP: alkaline phosphatase, MDA: malondialdehyde.