Mildly Elevated Pulmonary Artery Systolic Pressure is Associated with Extracorporeal Membrane Oxygenation Support after Heart Transplantation
Table 1
Characteristics of HTx recipients stratified by preoperative PASP.
Demographics
PASP < 35 mmHg n = 28
PASP 35–50 mmHg n = 38
PASP > 50 mmHg n = 36
value
Age (years)
49.4 ± 15.3
50.5 ± 11.3
45.3 ± 9.7
0.64
Body mass index (kg/m2)
22.2 ± 3.8
23.9 ± 3.7
21.6 ± 3.4
0.087
Female (%)
7 (25)
9 (23.7)
7 (19.4)
0.87
Prior cardiac surgery (%)
4 (14.3)
8 (21.1)
3 (8.3)
0.32
Ischemic time (min)
232.8 ± 95.7
212.4 ± 115.4
246.8 ± 105.0
0.42
Preoperative
Brain natriuretic peptide (ng/L)
3460.6 ± 3896.5
4524.4 ± 3862.7
6243.7 ± 6686.2
0.056
Cardiac troponin T (μg/L)
0.2 ± 0.6
0.1 ± 0.1
0.2 ± 0.3
0.14
Total cholesterol (mmol/l)
29.4 ± 22.2
23.9 ± 26.5
25.8 ± 12.4
0.21
Albumin (g/L)
41.7 ± 7.2
41.7 ± 7.2
41.1 ± 7.4
0.33
Alanine aminotransferase (IU/L)
22.3 ± 10.3
71.5 ± 99.8
27 ± 26.3
0.7
Aspartate aminotransferase (IU/L)
61.8 ± 88.4
59.8 ± 84.9
69.4 ± 99.5
0.062
Lactate dehydrogenase (U/L)
297.5 ± 160.3
234 ± 104.9
293.3 ± 110.3
0.3
Glomerular filtration rate (ml/min)
78.8 ± 31.8
75.5 ± 30.1
73.1 ± 28.5
0.73
Serum creatinine (μmoI/L)
122.8 ± 85.1
111.3 ± 54.2
140.0 ± 136.7
0.6
Left ventricular end-diastolic dimension (mm)
61.3 ± 14.9
67.1 ± 13.8
67.5 ± 14.7
0.084
Left ventricular ejection fraction (%)
36.2 ± 15.8
31.8 ± 14.9
27.5 ± 10.8
0.18
Cardiac output (L/min)
3.8 ± 0.8
3.3 ± 1.5
3.5 ± 1.3
0.59
Cardiac index (min/m2)
2.3 ± 0.5
2.0 ± 1.0
2.1 ± 0.9
0.31
Systolic blood pressure (mmHg)
107.8 ± 31.6
100.6 ± 18.3
95.6 ± 11.0
0.87
Diastolic blood pressure (mmHg)
71.4 ± 20.6
64.2 ± 19.8
62.8 ± 9.1
0.85
Pulmonary artery diastolic pressure (mmHg)
10.8 ± 2.7
21.9 ± 5.7
33.5 ± 10.3
<0.001
Pulmonary artery wedge pressure (mmHg)
11.9 ± 5.3
19.6 ± 5.5
27.9 ± 7.1
<0.001
PVR (Wood unit)
3.3 ± 1.6
4.3 ± 2.7
5.6 ± 2.4
0.007
Right atrial pressure (mmHg)
8.9 ± 6.6
11.9 ± 3.6
12.9 ± 5.9
0.23
Intraoperative
Aortic cross-clamping time (min)
40.7 ± 16.6
40.8 ± 12.0
46.7 ± 10.8
0.28
CPB time (min)
127.3 ± 23.5
152 ± 41.3
169 ± 40.4
0.21
Postoperative
Intensive care unit time (hour)
272.3 ± 142.7
476.5 ± 334.6
369.7 ± 228.8
0.071
Mechanical ventilation time (hour)
53 ± 17.3
133.8 ± 173.7
45.9 ± 29.3
0.71
Left ventricular end-diastolic dimension (mm)
42.3 ± 7.1
45.1 ± 3.1
41.6 ± 4.3
0.26
Left ventricular ejection fraction (%)
60.6 ± 6.4
60.7 ± 4.6
64.2 ± 2.8
0.019
Brain natriuretic peptide (ng/L)
10082.6 ± 10413.3
2606.4 ± 2009.4
9138 ± 6781.2
0.12
Cardiac troponin T (μg/L)
0.6 ± 0.5
0.5 ± 0.1
0.9 ± 0.6
0.13
Total cholesterol (mmol/l)
16.8 ± 8.6
22.4 ± 16.9
30.6 ± 19.3
0.68
Albumin (g/L)
38.1 ± 7.2
42.7 ± 6.4
37.2 ± 3.3
0.55
Alanine aminotransferase (IU/L)
24.6 ± 28.7
28.6 ± 18.1
21.6 ± 11.8
0.25
Aspartate aminotransferase (IU/L)
18.4 ± 21.0
17.6 ± 5.8
21 ± 15.2
0.15
Lactate dehydrogenase (U/L)
279.7 ± 97.9
333 ± 68.7
315.4 ± 74.5
0.032
Glomerular filtration rate (ml/min)
64.6 ± 36.2
71.9 ± 29.3
73.2 ± 24.9
0.7
Serum creatinine (μmoI/L)
153.7 ± 129.0
99.9 ± 36.5
113 ± 40.5
0.67
Renal replacement therapy (%)
7 (25%)
9 (23.7%)
8 (22.2%)
0.97
ECMO (%)
1 (3.6%)
12 (31.6%)
11 (30.6%)
0.007
Data are presented as mean ± standard deviation or n (%). PASP: pulmonary artery systolic pressure; PVR: pulmonary vascular resistance; CPB: cardiopulmonary bypass; ECMO: extracorporeal membrane oxygenation. Bold values mean the P value was less than 0.05, which was considered statistically significant.
