Mildly Elevated Pulmonary Artery Systolic Pressure is Associated with Extracorporeal Membrane Oxygenation Support after Heart Transplantation
Table 2
Characteristics of HTx recipients with and without postoperative ECMO support.
Demographics
ECMO n = 24
No ECMO n = 78
value
Age (years)
47.6 ± 15.8
48.7 ± 12.4
0.96
Body mass index (kg/m2)
22.8 ± 3.2
22.6 ± 3.2
0.8
Female (%)
6 (25%)
17 (21.8%)
0.74
Prior cardiac surgery (%)
4 (16.7%)
11 (14.1%)
0.76
Ischemic time (min)
227.5 ± 120.4
203 ± 105.3
0.97
Preoperative
Brain natriuretic peptide (ng/L)
6620.2 ± 6017.2
4723.4 ± 4916.3
0.2
Cardiac troponin T (μg/L)
0.1 ± 0.2
0.1 ± 0.4
0.94
Total cholesterol (mmol/l)
30.5 ± 20.8
26.2 ± 20.9
0.29
Albumin (g/L)
46.5 ± 23.5
41.5 ± 7.1
0.79
Alanine aminotransferase (IU/L)
26.2 ± 18.9
41.7 ± 89.3
0.37
Aspartate aminotransferase (IU/L)
27.6 ± 12.0
41.9 ± 48.8
0.34
Lactate dehydrogenase (U/L)
416.1 ± 235.4
275.2 ± 109.7
0.035
Glomerular filtration rate (ml/min)
63.7 ± 25.8
71.9 ± 29.1
0.36
Serum creatinine (μmoI/L)
110.5 ± 51.5
123.0 ± 94.6
0.76
Left ventricular end-diastolic dimension (mm)
69.5 ± 11.5
65.2 ± 14.6
0.22
Left ventricular ejection fraction (%)
30.6 ± 9.3
32.0 ± 15.0
0.49
Cardiac output (L/min)
3.9 ± 1.4
3.7 ± 1.3
0.54
Cardiac index (min/m2)
2.3 ± 0.7
2.4 ± 1.5
0.64
Systolic blood pressure (mmHg)
102.1 ± 17.9
101.8 ± 18.5
0.67
Diastolic blood pressure (mmHg)
63.4 ± 12.1
63.6 ± 13.8
0.58
PASP (mmHg)
52.9 ± 19.0
43.6 ± 14.8
0.024
Pulmonary artery diastolic pressure (mmHg)
24.7 ± 11.5
20.3 ± 11.1
0.072
Pulmonary artery wedge pressure (mmHg)
23.6 ± 8.3
20.0 ± 8.5
0.13
PVR (Wood unit)
3.9 ± 2.6
4.4 ± 2.5
0.42
Right atrial pressure (mmHg)
13.8 ± 7.9
11.8 ± 5.9
0.36
Intraoperative
Aortic cross-clamping time (min)
54.6 ± 20.4
48.3 ± 17.0
0.19
CPB time (min)
247.7 ± 73.1
168.4 ± 67.9
<0.001
Postoperative
Intensive care unit time (hour)
501.4 ± 307.1
384.6 ± 313.0
0.036
Mechanical ventilation time (hour)
197.0 ± 102.1
62.1 ± 59.0
<0.001
Left ventricular end-diastolic dimension (mm)
40.9 ± 4.8
43.2 ± 4.6
0.021
Left ventricular ejection fraction (%)
58.7 ± 13.0
62.2 ± 5.5
0.74
Brain natriuretic peptide (ng/L)
13049.9 ± 12787.7
7032.2 ± 9752.5
0.016
Cardiac troponin T (μg/L)
1.4 ± 2.1
0.7 ± 0.8
0.032
Total cholesterol (mmol/l)
76.8 ± 82.6
30.1 ± 45.2
0.2
Albumin (g/L)
40.0 ± 4.7
38.8 ± 5.8
0.2
Alanine aminotransferase (IU/L)
36.3 ± 52.6
27.6 ± 25.3
0.27
Aspartate aminotransferase (IU/L)
36.5 ± 34.3
22.4 ± 19.1
0.019
Lactate dehydrogenase (U/L)
549.2 ± 484.9
317.5 ± 108.7
<0.001
Glomerular filtration rate (ml/min)
56.6 ± 31.0
69.3 ± 31.2
0.078
Serum creatinine (μmoI/L)
154.7 ± 90.2
135.8 ± 99.9
0.055
Renal replacement therapy (%)
10 (41.7%)
14 (17.9%)
0.017
Data are presented as mean ± standard deviation or n (%). PASP: pulmonary artery systolic pressure; PVR: pulmonary vascular resistance; CPB: cardiopulmonary bypass; ECMO: extracorporeal membrane oxygenation. Bold values mean the P value was less than 0.05, which was considered statistically significant.
