The Effects of Propafenone on Postoperative Atrial Fibrillation in Adult Patients Undergoing Cardiac Surgery: A Meta-Analysis of Randomized Controlled Trials
Table 3
Influence of statistical model on estimated treatment effects of primary outcomes.
Outcomes
Effects
Heterogeneity
OR (95% CI)
Overall effect
FEM
REM
FEM
REM
Postoperative arrhythmia (%)
Atrial fibrillation
Prevent
0
0.41
0.52 (0.30, 0.89)
0.52 (0.30, 0.89)
0.02
0.02
Atrial flutter
Prevent
42
0.19
1.07 (0.23, 4.89)
1.03 (0.09, 12.20)
0.93
0.98
Atrial arrhythmia
Prevent
35
0.20
0.70 (0.46, 1.07)
0.69 (0.40, 1.18)
0.10
0.18
Supraventricular tachyarrhythmias
Prevent
0
0.98
1.17 (0.52, 2.66)
1.17 (0.52, 2.66)
0.70
0.70
Incidence of conversion from AF to sinus rhythm (%)
20 min after administration
Treatment
0
0.46
5.39 (2.25, 12.91)
5.12 (2.10, 12.49)
0.0002
0.0003
1 hour after administration
Treatment
0
0.73
2.89 (1.50, 5.57)
2.89 (1.50, 5.59)
0.002
0.002
24 hours after administration
Treatment
40
0.16
0.63 (0.38, 1.04)
0.57 (0.27, 1.22)
0.07
0.15
Atrial fibrillation recurrence (%)
Treatment
24
0.27
0.72 (0.40, 1.29)
0.69 (0.32, 1.50)
0.27
0.35
Postoperative adverse events (%)
Total adverse events
Prevent/treatment
0
0.47
1.04 (0.70, 1.55)
1.07 (0.71, 1.62)
0.85
0.75
Hypotension
Treatment
0
0.49
0.29 (0.09, 0.92)
0.29 (0.09, 0.95)
0.04
0.04
Bradycardia
Treatment
31
0.23
1.09 (0.45, 2.62)
0.93 (0.28, 3.13)
0.85
0.91
Discontinued due to adverse events (%)
Prevent/treatment
51
0.11
1.02 (0.65, 1.61)
0.93 (0.46, 1.90)
0.93
0.84
CI: confidence interval, FEM: fixed effects model, OR: odds ratio, and REM: random effects models.
