Comparison of United States and Canadian Glaucoma Medication Costs and Price Change from 2006 to 2013

Table 2

Glaucoma topical medications price change from 2006 to 2013 in the USA and Canada.

Product name	Active ingredient	Conc. %	2006 unit price		2006 unit price in 2013 dollars^3		2013 unit price		Inflation adjusted % change
			AWP^1	ODBP^2	AWP^1	ODBP^2	AWP^1	ODBP^2	AWP^1	ODBP^2
			$US	$Cdn	$US	$Cdn	$US	$Cdn	%	%
Brand
Prostaglandins
Lumigan	Bimatoprost	0.01	26.79	10.40	30.97	11.77	50.25	11.12	62%	−6%
Travatan Z	Travoprost	0.004	23.88	10.60	27.61	12.00	46.25	11.26	68%	−6%
Xalatan	Latanoprost	0.005	23.54	10.40	27.21	11.77	52.44	11.18	93%	−5%
β-Blockers
Betoptic S	Betaxolol	0.25	9.20	2.23	10.64	2.52	20.66	2.34	94%	−7%
Timoptic-XE	Timolol	0.25	—	3.26	—	3.69	31.80	4.29	—	16%
Timoptic-XE	Timolol	0.5	6.72	3.90	7.77	4.41	34.85	5.13	349%	16%
α2-Agonists
Alphagan P	Brimonidine	0.15	9.32	2.31	10.77	2.61	22.41	2.38	108%	−9%
Carbonic anhydrase inhibitors
Azopt	Brinzolamide	1.0	7.56	3.22	8.74	3.65	15.69	3.34	80%	−8%
Trusopt	Dorzolamide	2.0	6.18	3.30	7.14	3.74	9.20	3.94	29%	5%
Combination
Combigan	Brimonidine/timolol	0.2–0.5	—	3.94	—	4.46	22.50	4.13	—	−7%
Cosopt	Dorzolamide/timolol	2.0–0.5	11.33	5.00	13.10	5.66	16.89	5.99	29%	6%
Generic^4
Prostaglandins
Latanoprost	Latanoprost	0.005	—	—	—	—	22.05	3.83	—	—
β-Blockers
Levobunolol	Levobunolol	0.25	2.93	0.93	3.38	1.06	2.72	0.93	−20%	−12%
Levobunolol	Levobunolol	0.5	3.23	1.23	3.73	1.40	4.08	1.15	9%	−18%
Timolol	Timolol	0.25	2.35	1.28	2.71	1.45	2.76	0.97	2%	−33%
Timolol	Timolol	0.5	3.23	1.51	3.74	1.71	2.88	1.21	−23%	−29%
Timolol-XE	Timolol-XE	0.25	5.42	—	6.26	—	9.90	1.96	58%	—
Timolol-XE	Timolol-XE	0.5	6.44	—	7.44	—	11.70	2.34	57%	—
α2-Agonists
Brimonidine	Brimonidine	0.15	—	—	—	—	20.17	1.73	—	—
Brimonidine	Brimonidine	0.2	6.52	1.65	7.54	1.87	8.27	1.16	10%	−38%
Combination
Dorzolamide/timolol	Dorzolamide/timolol	2.0–0.5	—	—	—	—	10.88	4.26	—	—

Average Wholesale Price from Red Book.
²Ontario Drug Benefit Price.
³Inflation from 2006 to 2013 estimated to be 15.6% for USA and 13.2% for Canada.
⁴Generic price is an average of all generic companies offering the medication.