Suppression of In Vivo Neovascularization by the Loss of TRPV1 in Mouse Cornea

Figure 5

Expression of mRNAs of angiogenic or inflammatory components in centrally cauterized cornea at day 3. mRNA expression of vascular endothelial growth factor (VEGF, (a)) and transforming growth factor β1 (TGFβ1, (b)) mRNAs in the affected cornea of wild-type (WT) was more marked as compared with that in TRPV1-null (KO) mice at day 3 after cauterization. The loss of TRPV1 did not affect mRNA expression level of substance P (c) and IL-6 (d) in the centrally cauterized cornea at this timepoint. < 0.05; n.s.: not significant.

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