Factors Contributing to Long-Term Severe Visual Impairment in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis

Table 1

Causative agents associated with SJS/TEN patients and relative frequencies.

Inciting agents	Number of patients ()	Percentage (%)
Medications	83	93.26
Single possible drug	58	64.04
Antibiotics	25	28.09
Penicillins	8	8.99
Sulfonamides	8	8.99
Tetracyclines	2	2.25
Quinolones	1	1.12
Macrolides	1	1.12
Other antibiotics	5	5.62
Anticonvulsants	10	11.24
Carbamazepine	6	6.74
Phenytoin	3	3.37
Phenobarbital	1	1.12
Allopurinol	11	12.36
NSAIDs	4	4.49
Antimalarials	2	2.25
Antivirals	2	2.25
Other drugs	4	4.49
Multiple possible drugs	25	28.09
Multiple antibiotics	7	7.87
Antibiotics + anticonvulsants	5	5.62
Antibiotics + NSAIDs	2	2.25
Antibiotics + antivirals	1	1.12
Antibiotics + bromhexine	1	1.12
Multiple nonantibiotics	9	10.11
Nonpharmaceutical triggers	6	6.74
Infections	3	3.37
Mycoplasma	1	1.12
Herpes simplex	2	2.25
Unidentified	3	3.37
Total	89	100

More than one possible drug was identified.