Suppression of Retinal Neovascularization by Inhibition of Galectin-1 in a Murine Model of Oxygen-Induced Retinopathy

Figure 6

OTX008 reduced the number of preretinal neovascular cells. (a) RA group. (b) OIR-OTX008 group. (c) OIR group. (d) OIR-PBS group. At P17, sections from four groups were stained with H&E. Black arrows indicate the preretinal neovascular cells on the vitreous side of internal limiting membrane. Magnification 400x, scale . (e) Quantification of preretinal neovascular cells. Quantification analysis revealed that intravitreal injection of OTX008 reduced the number of neovascular cells in the OIR-OTX008 group compared to those in the OIR group and in the OIR-PBS group. RA group versus OIR group, , ; OIR-OTX008 group versus OIR group, , , OIR-OTX008 group versus OIR-PBS group, , ; data were presented as the mean ± SD, per group.

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