ATF4 Involvement in TLR4 and LOX-1-Induced Host Inflammatory Response to Aspergillus fumigatus Keratitis

Figure 1

ATF4 was increased in mice corneas of A. fumigatus keratitis developed by intrastromal injection. (a) Significant corneal opacity of C57BL/6 mouse models was developed by intrastromal injection formed 1 day after infection and persisted up to 14 days. Corneal inflammation gradually improved with increased neovascularization. (b) After A. fumigatus infection, ATF4 protein expression was confirmed by western blot to be degraded in mouse corneas at 1 day after infection, elevated at 3 days, and then persisted up to 7 days. As the inflammation subsided, ATF4 expression returned to normal after 10 days. Mean values and standard deviations of two independent experiments are shown; , .

(a)

(b)