ATF4 Involvement in TLR4 and LOX-1-Induced Host Inflammatory Response to Aspergillus fumigatus Keratitis

Figure 5

ERK1/2 and JNK contributed to expression of ATF4 in response to A. fumigatus. With pretreatment of an ERK1/2 inhibitor, ATF4 protein levels in infected mouse corneas (a) 1 day after infection and HCECs (b) 16 hours after A. fumigatus infection were significantly lower. ATF4 protein levels in infected mouse corneas (c) and HCECs (d) are significantly lower with pretreatment by JNK inhibitors. The mean values and standard deviations of two independent experiments are shown; , , .

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