Efficacy of Osthole in Management of Hypoperfused Retina

Figure 4

Double immunofluorescent staining of NF-κB, Akt, Bax, and Bcl-2 on the 5th day. NF-κB, Akt, Bax, and Bcl-2 levels on day 5 with double immunofluorescent staining. Akt and NF-κB staining were significantly more prevalent in the model group than in the control group. In addition, NF-κB expression in the osthole-IG group is higher than that in the other treated groups (a). Bax signaling was more prevalent, while Bcl-2 staining was less prevalent, in the osthole-IG group than in the model group. Also, Bcl-2 staining was less prevalent in the osthole-PI, ginaton, and aspirin groups than in the model group but higher than in the osthole-IG group (b).

(a)

(b)