Neurodegeneration in Patients with Type 2 Diabetes Mellitus without Diabetic Retinopathy
Table 1
Mean and standard deviation (in parentheses) of full retinal, ganglion cell layer, and retinal nerve fiber layer thickness (in microns) in the macular area, measured with Spectralis OCT in healthy controls and patients with DM2.
Macular parameters
Healthy
DM2
Mean (±SD)
Mean (±SD)
Total thickness
Center
282.88 (±18.23)
275.62 (±19.18)
0.035
Inner superior
350.82 (±11.51)
335.38 (±14.77)
<0.001
Inner nasal
355.23 (±11.94)
337.77 (±15.67)
<0.001
Inner inferior
347.37 (±10.64)
331.67 (±14.79)
<0.001
Inner temporal
338.13 (±9.66)
323.40 (±14.79)
<0.001
Outer superior
302.20 (±14.76)
291.90 (±14.73)
<0.001
Outer nasal
318.38 (±13.42)
307.33 (±14.29)
<0.001
Outer inferior
289.48 (±13.05)
279.32 (±14.25)
<0.001
Outer temporal
288.08 (±13.67)
280.13 (±14.03)
0.002
GCL thickness
Center
16.53 (±6.01)
16.63 (±4.18)
0.908
Inner superior
54.17 (±4.23)
49.59 (±5.99)
<0.001
Inner nasal
53.90 (±4.78)
48.00 (±6.48)
<0.001
Inner inferior
54.29 (±3.98)
48.96 (±5.98)
<0.001
Inner temporal
49.44 (±4.18)
43.63 (±6.49)
<0.001
Outer superior
35.97 (±3.22)
33.56 (±3.22)
<0.001
Outer nasal
39.16 (±3.28)
36.50 (±3.76)
<0.001
Outer inferior
33.38 (±3.24)
31.85 (±3.71)
0.014
Outer temporal
36.38 (±3.76)
33.91 (±4.68)
0.001
Total volume
1.11 (±0.10)
1.03 (±0.75)
<0.001
RNFL thickness
Center
13.12 (±1.67)
13.02 (±1.66)
0.752
Inner superior
23.73 (±2.89)
23.89 (±2.89)
0.782
Inner nasal
21.25 (±2.35)
20.95 (±2.68)
0.502
Inner inferior
25.70 (±3.10)
24.67 (±3.09)
0.065
Inner temporal
17.55 (±1.61)
17.64 (±1.56)
0.742
Outer superior
37.09 (±4.99)
36.69 (±6.76)
0.700
Outer nasal
49.34 (±7.45)
47.45 (±7.10)
0.139
Outer inferior
40.29 (±6.33)
37.94 (±6.08)
0.033
Outer temporal
19.31 (±1.64)
19.39 (±1.63)
0.781
Total volume
0.92 (±0.10)
0.89 (±0.10)
0.137
Bold letters indicate statistical significance (). Asterisks mark statistical significance using Bonferroni correction (). DM, diabetes mellitus; SD, standard deviation; GCL, ganglion cell layer; RNFL, retinal nerve fiber layer.
