Hypothyroidism is Not Associated with Keratoconus Disease: Analysis of 626 Subjects

Table 2

Anterior corneal surface parameters measured with the TMS-5 in different disease groups.

Disease group	SAI	SRI	KCI	KSI	KPI
1. Euthyroid without keratoconus (n = 75)	0.55 ± 0.36	0.30 ± 0.36	2.29 ± 6.43	1.79 ± 5.76	0.21 ± 0.02
	0.44; 0.37	0.19; 0.35^a	0.00; 0.00	0.00; 0.00	0.21; 0.03
2. Euthyroid with keratoconus (n = 341)	2.57 ± 1.41	1.08 ± 0.62	64.08 ± 34.38	53.83 ± 25.97	0.36 ± 0.11
	2.52; 1.86^b	1.01; 0.93	76.80; 58.50	56.90; 39.90	0.36; 0.16^b
3. Hypothyroid without keratoconus (n = 57)	0.47 ± 0.31	0.17 ± 0.23	4.76 ± 10.73	2.72 ± 8.26	0.21 ± 0.02
	0.39; 0.33	0.07; 0.19	0.00; 0.00	0.00; 0.00	0.21; 0.03
4. Hypothyroid with keratoconus (n = 68)	2.55 ± 1.42	1.15 ± 0.62	60.62 ± 34.71	57.46 ± 27.21	0.35 ± 0.34
	2.39; 1.97	1.06; 0.89	69.65; 60.80	61.35; 41.85	0.34; 0.17
Difference between groups
1-2
3-4
1–3	—		—	—	—
2–4	—	—	—	—	—

Values represent the mean ± standard deviation or the median; interquartile range, as indicated. ^aFor this group, n = 74; ^bfor this group, n = 340; ; . SAI: surface asymmetry index; SRI: surface regularity index; KCI: Klyce/Maeda keratoconus index; KSI: Smolek/Klyce keratoconus severity index; KPI: keratoconus prediction index.