PPARG Polymorphisms Are Associated with Unexplained Mild Vision Loss in Patients with Type 2 Diabetes Mellitus
Table 4
Genotypic association analysis in 135 residents with unexplained mild visual impairment (UMVI) and 133 residents with normal vision (NV).
SNP
Genotype
UMVI residents
NV residents
HWpval
value
OR (95% CI)
value#
OR# (95% CI)
number
number
rs10865710
GG
36
0
0.08
7.17E − 42
NA
GC
91
14
6.40 (3.47–11.80)
1.86E − 41
0.01 (0.00–0.02)
CC
8
119
0.07 (0.03–0.14)
(CC: GG + GC)
rs1801282
GG
0
0
1
NA
NA
GC
22
0
NA
7.46E − 6
0.46 (0.40, 0.53)
CC
113
133
0.86 (0.61–1.21)
(CC: GG + GC)
rs709158
GG
25
4
0.33
3.35E − 09
4.43 (1.46–13.43)
0.41
2.22 (0.67, 7.38)
GA
45
16
1.94 (1.00–3.78)
6.9E − 7
20.46 (5.84, 71.61)
AA
11
36
0.21 (0.10–0.45)
1.39E − 6
0.11 (0.04, 0.26)
rs3856806
TT
16
0
0.10
1.24E − 10
NA
TC
56
21
2.63 (1.51–4.58)
8.92E − 10
0.16 (0.09–0.29)
CC
63
112
0.55 (0.37–0.82)
(CC: TT + TC)
value (chi-square test); OR (95% CI) (chi-square test); OR# (95 % CI); value# (Bonferroni correction); OR’ (Bonferroni correction); HWpval, Hardy–Weinberg equilibrium p value. OR = odds ratio; CI = confidence interval; NA, the odds ratio was not available where the number of individuals with two copies of the risk allele was zero. χ2 test.
