Research Article

Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes

Figure 1

Concentrations of conbercept in the AH (a) and the VH (b) following administration of a single 0.5 mg dose to the left eyes in the subretinal group, the intravitreal group, and the intravitreal nonvitrectomized group. Conbercept concentration-time profiles for the AH and the VH are shown. The results are presented as the mean and upper error bar. A t-test was used for inferential statistics. (c) The concentration of conbercept in the retina was examined 4 weeks after injection. The results are presented as the mean and upper error bar. The U test was used for inferential statistics. , , and .
(a)
(b)
(c)