Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes

Figure 2

(a, b) A slight uplift of the retina caused by the volume of the drug solution was observed in two eyes (two rabbits) of the subretinal group 24 hours after injection. The height of the uplift was measured (the yellow straight line). (c–h) B-ultrasonography of the six eyes (six rabbits) in the subretinal group 2 to 4 weeks after conbercept injection. The slight uplift of the retina reverted to a flat state in (e) and (f). No retinal detachment or vitreous hemorrhage was observed.