Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes

Figure 4

Sections of the rabbit retina labeled with hematoxylin and eosin: eyes from the subretinal group (subretinal injection into vitrectomized eyes), the intravitreal group (intravitreal injection into vitrectomized eyes), and the control group (intravitreal injection into nonvitrectomized eyes) with conbercept injection 1 week and 2 weeks postoperatively. The histological examinations show the complete structure of all retinal layers in the eyes of the 3 groups. No signs of atrophy, disorganization, cell loss, or hypocellularity were observed. The scale bar is 50 μm.