Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes

Table 1

Pharmacokinetic parameters of the conbercept model in aqueous humor.

Parameters	Intravitreal injection (vitrectomized; n = 6)	Subretinal injection (vitrectomized; n = 6)	Intravitreal injection (nonvitrectomized; n = 6)	value
Cmax (μg/ml)^†	14.49 ± 3.40	11.75 ± 3.38	13.43 ± 1.59
Tmax (days)^††	1.00 ± 0.00	1.00 ± 0.00	1.00 ± 0.00
Half-life (days)^†	3.34 ± 0.58	9.88 ± 6.48	4.30 ± 1.78
AUC0-t (μg day/ml)^†	66.81 ± 18.42	79.56 ± 30.58	64.76 ± 6.85
AUC0-∞ (μg day/ml)^†	67.02 ± 18.36	89.38 ± 25.60	65.49 ± 7.07
AUMC0-t (μg day^2/ml)^††	310.76 ± 96.32	618.20 ± 239.12	332.31 ± 32.21
AUMC0-∞ (μg day^2/ml)^†	317.83 ± 95.23	1105.85 ± 474.77	359.66 ± 59.79
MRT0-t (days)^†	4.62 ± 0.49	7.85 ± 0.89	5.15 ± 0.41
MRT0-∞ (days)^†	4.72 ± 0.50	13.10 ± 6.94	5.49 ± 0.68

C_max, maximum concentration; T_max, the time at which the concentration was maximum; AUC, area under the curve; AUMC, area under the first moment curve; MRT, mean residence time.^†t-test: comparison of the parameters in the intravitreal group (vitrectomized) and the subretinal group (vitrectomized).^††U test: comparison of the parameters in the intravitreal group (vitrectomized) and the subretinal group (vitrectomized). The parameters were calculated by a noncompartmental model, and , , and were considered to indicate significance.