Intraocular Pharmacokinetics and Safety of Subretinal Injection Compared with Intravitreal Application of Conbercept in Vitrectomized Rabbit Eyes

Table 2

Pharmacokinetic parameters of the conbercept model in vitreous humor.

Parameters	Intravitreal injection (vitrectomized; n = 6)	Subretinal injection (vitrectomized; n = 6)	Intravitreal injection (nonvitrectomized; n = 6)	value
Cmax (μg/ml)^††	147.16 ± 34.44	121.63 ± 27.59	140.45 ± 25.81
Tmax (days)^††	1.00 ± 0.00	1.33 ± 0.82	1.33 ± 0.82
Half-life (days)^†	3.12 ± 0.45	6.14 ± 1.69	4.12 ± 0.98
AUC0-t (μg day/ml)^†	628.08 ± 145.71	1318.15 ± 243.56	1039.69 ± 243.99
AUC0-∞ (μg day/ml)^†	629.48 ± 145.76	1384.53 ± 272.42	1053.33 ± 254.53
AUMC0-t (μg day^2/ml)^†	2653.01 ± 891.88	10633.25 ± 3431.12	6447.03 ± 2108.65
AUMC0-∞ (μg day^2/ml)^†	2699.37 ± 901.33	13171.78 ± 4838.04	6927.17 ± 2518.34
MRT0-t (days)^†	4.15 ± 0.55	7.90 ± 1.25	6.09 ± 0.60
MRT0-∞ (days)^†	4.22 ± 0.58	9.25 ± 1.89	6.42 ± 0.86

C_max, maximum concentration; T_max, the time at which the concentration was maximum; AUC, area under the curve; AUMC, area under the first moment curve; MRT, mean residence time.^†t-test: comparison of the parameters in the intravitreal group (vitrectomized) and the subretinal group (vitrectomized).^††U test: comparison of the parameters in the intravitreal group (vitrectomized) and the subretinal group (vitrectomized). The parameters were calculated by the noncompartmental model, and , , and were considered to indicate significance.