Identification of Key Genes and Pathways Associated with Age-Related Macular Degeneration

Table 2

Functional analysis for the DEGs in in RPE/choroid between AMD patients and age-matched healthy controls.

Top diseases and biological functions	value^a	No. of genes
Diseases and disorders
Cancer	5.96E-16-2.41E-03	299
Organismal injury and abnormalities	5.96E-16-2.41E-03	301
Ophthalmic disease	9.88E-16-2.26E-03	58
Hereditary disorder	2.26E-15-2.26E-03	75
Neurological disease	2.26E-15-2.17E-03	126
Molecular and cellular functions
Cell morphology	1.01E-12-2.19E-03	56
Cellular movement	1.82E-10-2.19E-03	84
Cellular compromise	6.25E-10-1.88E-03	27
Cellular development	1.48E-09-2.25E-03	32
Cellular growth and proliferation	1.48E-09-2.25E-03	46
Physiological system development and function
Nervous system development and function	7.04E-14-1.88E-03	88
Embryonic development	1.01E-12-2.06E-03	55
Organ development	1.01E-12-1.86E-03	48
Organ morphology	1.01E-12-1.69E-03	58
Organismal development	1.01E-12-2.37E-03	87

^aRange of p values indicates a higher level functions that contained multiple lower level functions.