Evaluation of Functional Outcomes and OCT-Biomarkers after Intravitreal Dexamethasone Implant for Postoperative Cystoid Macular Edema in Vitrectomized Eyes
Table 3
Baseline predictors of final visual outcome after 12 months after the first DEX injection.
Baseline measure
CDVA loss >1 line n (%)
CDVA gain or loss ≤1 line n (%)
CDVA gain >1 line n (%)
value
OR (95% CI)
Baseline CDVA (log MAR ± SD)†
0.47 ± 0.34
0.50 ± 0.26
0.70 ± 0.30
0.001
1.485 (1.171–1.884)
Indication for surgery
0.046
1.168 (1.003–1.360)
ERM
5/46 (11)
6/46 (13)
35/46 (76)
RRD
4/15 (27)
4/15 (27)
7/15 (46)
Lens status
0.820
1.015 (0.890–1.159)
Phakic
3/27 (11)
5/27 (19)
19/27 (70)
Pseudophakic
6/34 (18)
5/34 (15)
23/34 (67)
Naïve status
0.853
0.946 (0.871–1.137)
Naïve
2/18 (11)
2/18 (11)
14/18 (78)
Previously treated
7/43 (16)
8/43 (19)
28/43 (65)
IRF/cysts
0.465
1.055 (0.915–1.216)
Absence of IRF/cysts
1/8 (12)
2/8 (25)
5/8 (63)
Presence of IRF/cysts
7/53 (13)
8/53 (15)
38/53 (72)
SRF
0.043
0.860 (0.743–0.995)
Absence of SRF
8/43 (19)
9/43 (21)
26/43 (60)
Presence of SRF
0/18 (0)
1/18 (6)
17/18 (94)
EZ continuity
0.209
1.094 (0.951–1.257)
Completely continuous
4/12 (33)
2/12 (17)
6/12 (50)
Partially disrupted
3/31 (10)
3/31 (10)
25/31 (80)
Completely disrupted
1/18 (6)
5/18 (28)
12/18 (66)
Onset of PCME to surgery
0.827
0.985 (0.871–1.137)
<3 months
7/38 (18)
3/38 (8)
28/38 (74)
>3 months
2/23 (9)
7/23 (30)
14/23 (61)
Time between surgery and first DEX
0.982
0.999 (0.901–1.107)
<6 months
6/36 (17)
7/36 (19)
23/36 (64)
>6 months
3/25 (12)
3/25 (12)
19/25 (76)
CDVA: corrected distance visual acuity; CI: confidence interval; ERM: epiretinal membrane; RRD: rhegmatogenous retinal detachment; IRF: intraretinal fluid; SRF: subretinal fluid; EZ: ellipsoid zone; PCME: postoperative cystoid macular edema; DEX: dexamethasone intravitreal implant. Odds ratio (OR) for a patient presenting with a gain of CDVA >1 line at 12 months when baseline measure is increased by 1 value. †For every less line (+0.1 log MAR) of baseline BCVA, a patient was more likely to gain >1 line in CDVA at 12 months after initial DEX injection.
