|
| Author (year) | Study design | Intervention | n | Age (years) | Follow-up | Conclusions |
|
| Totsuka (2018) | NRSI | Dichoptic therapy (Occlu-pad) | 72 (35 aniso) | 3–9 | 12 months | The Occlu-pad group showed greater improvement from the 6th month onward () |
| Patch | 66 (35 aniso) | 3–9 | 12 months | Adherence was better in the Occlu-pad group than the patching group (70%–34%) |
|
| Deshpande (2018) | NRSI | Perceptual learning + patch | 32 | 8–12 | 3 months | All subject showed total or partial improvement (3 lines) in VA |
| Perceptual learning + patch | 18 | 13–20 | 3 months | Better effect at 3 and 4 weeks |
|
| Iwata (2018) | NRSI | Dichoptic therapy (Occlu-pad) + glasses | 22 | 4.7 ± 1.2 | 6 months | Significant VA improvement () at 3 and 6 months |
| Good adherence to treatment (88.6% ± 18.9% under 3 months and 73.2% ± 18.9% between 3 and 6 months) |
|
| Gambacorta (2018) | NRSI | Dichoptic therapy | 13 | | | DT was better than PL but with no significance (). Likely due to the size of the sample |
| Perceptual learning | 16 | 7–17 | Variable | Anisometropic amblyopia improved 0.1 ± 0.03 logMAR after 10 h of training (DT or PL) |
| Similar results than patching. Shorter treatment time with DT and PL |
| Compliance of at least 69% |
|
| Kuruca (2015) | NRSI | Perceptual learning (CAM)-anisometropic | 15 | 4–10 | 6 months | Significant VA improvement in anisometropic amblyopes () |
| Perceptual learning (CAM)-strabismic | 14 | 4–10 | 6 months | |
|
| Birch (2015) | NRSI | R-G glasses + iPad videogame | 45 | 3.7–6.9 | 3 months | iPad videogame was better than sham iPad videogame |
| Sham iPad videogame (placebo) | 5 | 3.7–6.9 | 3 months | Significant VA improvement () |
| Compliance of at least 50% |
|
| Iwata (2018) | RCT | Glasses | 23 | 3–8 | 6 months | Occlu-pad and glasses were better than only glasses () |
| Dichoptic therapy (occlu-pad) + glasses | 23 | 3–8 | | Good adherence to Occlu-pad treatment (88.4 ± 18.7%) |
| Similar outcomes than patching |
|
| Singh (2017) | RCT | Monocular videogame + patch | 34 | 6–14 | 3 months | Monocular videogame and patch showed better results than only patch (2.4 lines logMAR/1.8 lines logMAR, ) |
| Patch | 34 | 6–14 | 3 months |
|
