Electrophysiological and Structural Changes in Chinese Patients with LHON

Table 2

Optical coherence tomography (OCT) measures of RNFL thickness around the optic disc (GCL + IPL) and RNFL thickness surrounding macula in group 1 (acute cases), group 2 (chronic cases), and in the control group.

		Group 1	Group 2	Control group
RNFL around optic disc	Number of eyes	3	13	10
	RNFL thickness (μm)	117 ± 12.1	66.1 ± 16.2	105.7 ± 8.1
Macula thickness	Number of eyes	5	15	10
	GCL + IPL thickness (μm)	57.0 ± 4.9	53.1 ± 2.5	71.7 ± 3.9
	RNFL thickness (μm)	31.8 ± 9.5	7.2 ± 7.1	35.4 ± 3.9

RNFL thickness around optic disc did not reduce in group 1 but reduced in group 2 (Group 1 vs. control, ; group 2 vs. control, ). The GCL + IPL thickness surrounding macular area (6 mm × 6 mm, centered on fovea) reduced in both groups (Group 1 vs. control, ; group 2 vs. control, ). The RNFL thickness surrounding macular area did not reduce in group 1 (), but reduced in group 2 (). RNFL: retinal nerve fiber layer; GCL + IPL: ganglion cell layer plus inner plexiform layer.