Electrophysiological and Structural Changes in Chinese Patients with LHON

Table 5

Summary of structural and functional characteristics.

Group 1	Group 2
Structural	Structural
OCT RNFL normal (3 of 5 eyes)	OCT RNFL reduced (15 of 15 eyes)
OCT GCL + IPL reduced (5 of 5 eyes)	OCT GCL + IPL reduced (15 of 15 eyes)
Functional	Functional
P50 normal (5 of 5 eyes)	P50 normal (10 of 11 eyes)
N95/P50 reduced (4 of 5 eyes)	N95/P50 reduced (11 of 11 eyes)
AD of ring 1 reduced (4 of 5 eyes)	AD of ring 1 reduced (16 of 17 eyes)
AD of ring 2 reduced (3 of 5 eyes)	AD of ring 1 reduced (15 of 17 eyes)
AD of ring 3 reduced (3 of 5 eyes)	AD of ring 1 reduced (13 of 17 eyes)

Structural measures are shown for “OCT RNFL” (thickness of the RNFL in macular OCT) and “OCT GCL + IPL” (thickness of GCL + IPL layer in macular OCT). Functional measures include the pattern ERG P50 amplitude, N95 : P50 amplitude ratio, and amplitude density (AD) of the mfERG in ring 1 (fovea) and rings 2 and 3.