Inhibiting the Progression of Human Retinoblastoma Cell by Downregulation of MMP-2/MMP-9 Using Short Hairpin RNAs (shRNAs) In Vitro

Figure 6

Potential MMP-2 and MMP-9 protein-protein interaction networks adopted from string database, version 11.0. (a) ACAN, aggrecan core protein; COL1A1, collagen alpha-1 (I) chain; COL18A1, collagen alpha-1 (XVIII) chain; DCN, cecorin; SRC, proto-oncogene tyrosine-protein kinase Src; STAT3, signal transducer and activator of transcription 3; TIMP 1/2/3, metalloproteinase inhibitor 1/2/3; VEGFA, vascular endothelial growth factor A. (b) CD44, cluster of differentiation 44; CDH1, cadherin-1; CXCL1, chemokine (C-X-C motif) ligand 1; MMP10, matrix metalloproteinase-10; PLG, plasminogen; SRC, proto-oncogene tyrosine-protein kinase Src; STAT3, signal transducer and activator of transcription 3; TIMP 1/2, metalloproteinase inhibitor 1/2; VEGFA, vascular endothelial growth factor A.

(a)

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