Effect of Repeated Intravitreal Ranibizumab and Aflibercept Injections on the Cornea in Patients with Age-Related Macular Degeneration

Table 2

Wilcoxon test for the endothelium cell density (ECD), the percentage of hexagonal cells (% Hex), and the coefficient of variation of cell size (CoV) before and after ranibizumab injections (RI) and aflibercept injections (AI).

	Ranibizumab; injections (RI)	Aflibercept; injections (AI)
	value	value
ECD before and after 1^st injection	0.022	<0.0001
ECD before and after 2^nd injection	0.041	<0.0001
ECD before and after 3^rd injection	0.0007	<0.0001
ECD before and 6 months after 1^st injection	0.000019	<0.0001
% Hex before and after 1^st injection	0.0043	0.038
% Hex before and after 2^nd injection	0.000002	0.024
% Hex before and after 3^rd injection	<0.0001	0.0018
% Hex before and 6 months after 1^st injection	<0.0001	0.00091
CoV before and after 1^st injection	0.14	0.72
CoV before and after 2^nd injection	0.000004	0.60
CoV before and after 3^rd injection	0.002	0.0073
CoV before and 6 months after 1^st injection	0.0003	0.0083