Association between Corneal Stiffness Parameter at the First Applanation and Keratoconus Severity
Table 1
Clinical parameters of normal and keratoconus eyes.
Parameters, median (IQR)
Normal eyes (N = 351)
Keratoconus eyes (N = 351)
Mild (N = 156)
Moderate (N = 142)
Severe (N = 53)
Age (years)
24.00 (19.00, 27.00)
24.00 (20.00, 30.00)
24.00 (20.00, 29.50)
25.00 (20.00, 30.00)
23.00 (19.00, 29.00)
0.356
0.133
CDVA (LogMAR)
0.00 (0.00, 0.00)
0.22 (0.10, 0.40)
0.10 (0.00, 0.19)
0.30 (0.15, 0.40)
0.40 (0.30, 0.70)
<0.001
<0.001
IOP (mmHg)
15.50 (14.50, 17.00)
13.50 (11.88, 15.00)
13.50 (12.50, 15.00)
13.00 (11.00, 14.63)
12.50 (10.00, 14.00)
<0.001
<0.001
AL (mm)
25.42 (24.71, 26.21)
25.15 (24.35, 25.99)
25.25 (24.48, 26.07)
25.17 (24.34, 25.87)
24.42 (23.48, 25.78)
0.0104
0.311
ACD (mm)
3.73 (3.55, 3.91)
3.81 (3.68, 3.97)
3.78 (3.66, 3.90)
3.85 (3.71, 4.04)
3.87 (3.52, 4.14)
0.001
0.383
MCD (cells/mm2)
3001.00 (2814.00, 3199.00)
2766.00 (2576.00, 2989.50)
2772.00 (2617.50, 3040.50)
2784.00 (2564.50, 2961.00)
2643.00 (2502.00, 2782.00)
<0.001
<0.001
Ks (D)
43.89 (42.78, 44.70)
47.90 (45.80, 51.00)
45.80 (45.05, 47.10)
50.20 (49.00, 51.83)
57.60 (56.00, 61.40)
<0.001
<0.001
Kf (D)
42.66 (41.60, 43.40)
44.85 (43.70, 47.00)
43.90 (43.00, 44.65)
46.65 (44.90, 48.10)
51.70 (48.50, 56.20)
<0.001
<0.001
Km (D)
43.30 (42.20, 44.05)
46.35 (44.80, 49.13)
44.80 (44.08, 45.80)
48.20 (46.90, 49.83)
54.80 (52.40, 58.90)
<0.001
<0.001
TCT (μm)
540.00 (519.00, 565.00)
461.50 (437.00, 492.00)
473.00 (446.50, 499.00)
458.00 (430.25, 478.25)
422.00 (389.00, 452.00)
<0.001
<0.001
CDVA, corrected distance visual acuity; IOP, intraocular pressure; AL, axial measurement; ACD, anterior chamber depth; MCD, mean endothelium cell density; Ks, steep keratometry; Kf, flat keratometry; Km, mean keratometry; TCT, thinnest corneal thickness. normal vs all keratoconus, normal vs mild keratoconus after general linear model.
