The Therapeutic Effects and Possible Mechanism of Pranoprofen in Mouse Model of Corneal Alkali Burns

Figure 4

The protein expression of NLRP3, IL-1β, IL-1β17p, and MMP-13 in the control group (A), saline group (B), and pranoprofen group (C) by performing western blot. The proteinic expression of (a) NLRP3, (b) IL-1β, IL-1β17p, and (c) MMP-13 in the control group (0.72 ± 0.024, 0.11 ± 0.002, 1.10 ± 0.028, and 0.30 ± 0.008) appeared to be significantly lower than the other two groups. Additionally, the protein expression of NLRP3, IL-1β, IL-1β17p, and MMP-13 of the saline group (1.23 ± 0.066, 2.03 ± 0.043, 2.45 ± 0.05, and 0.80 ± 0.030) were higher than those of the pranoprofen group (0.84 ± 0.008, 1.27 ± 0.022, 1.30 ± 0.020, and 0.36 ± 0.017). Data are shown as mean ± SD; n = 6, , , .

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