Efficacy of Voriconazole Corneal Intrastromal Injection for the Treatment of Fungal Keratitis

Table 1

Baseline demographic and clinical characteristics.

Characteristics	Study group
	TCSI group (n = 27)	Control group (n = 30)	Total (n = 57)	value^a
Gender, no.
Male	20	16	36	0.17
Female	7	14	21
Age, median (IQR), y	55 (49–65)	54 (45–62)	54 (47–65)	0.63
Occupation, no.
Agriculture	22	24	46	1.00
Nonagriculture^b	5	6	11
Medication use at enrollment, no.^c	16	19	35	0.79
Etiology, no.
Plant trauma	14	11	25	0.16
Others^d	8	6	14
None	5	13	18
Affected eye, no.
Right	12	14	26	1.00
Left	15	16	31
Visual acuity, median (IQR), LogMAR	0.90 (0.5–2)	1.1 (0.6–2.4)	1.0 (0.60–2.00)	0.37
Infiltrate or scar size, median (IQR), mm	3.9 (2.7–4.7)	3.8 (3.3–5.6)	3.8 (2.9–5.1)	0.44
Ulcer location, no.
Central	24	25	49	0.71
Peripheral	3	5	8
Hypopyon, no.
None	22	25	47	0.88
<0.5 mm	2	1	3
≥0.5 mm	3	4	7
% of depth, no.
>0–33	16	20	36	0.91
>33–67	9	8	17
>67–100	2	2	4
Epithelial defect, median (IQR), mm	2.5 (1.6–3.5)	2.6 (2.0–3.6)	2.5 (1.8–3.5)	0.55
Duration of symptoms, median (IQR), d	20 (7–45)	17.5 (10–30)	20 (10–30)	.80
Systemic disease, No.^e	8	6	14	.54

IQR, interquartile range. ^aThe count data were analyzed with Fisher’s exact test; the continuous data were analyzed with Wilcoxon’s rank-sum test. ^bIncludes unemployed, retired, etc. ^cIncludes topical ocular antifungals, systemic antifungals, topical antibiotics, lubricating eyedrops. ^dIncludes dust, finger, fingernail, sand, insect, iron rod. ^eIncludes diabetes mellitus, hypertension, hyperthyroidism, asthma, pulmonary heart disease.