Eyes that Do Not Meet the Eligibility Criteria of Clinical Trials on Age-Related Macular Degeneration: Proportion of the Real-World Patient Population and Reasons for Exclusion

Table 5

Comparison of the proportion of eyes that did not meet category 3 criteria among the three subtypes of neovascular age-related macular degeneration.

Characteristic	Typical neovascular AMD (N = 208)	PCV (N = 189)	Type 3 neovascularization (N = 69)	value
Eyes that did not meet at least one category 3 criterion	103 (49.5%)	89 (47.1%)	22 (31.9%)	0.036
Visual acuity criterion	80 (38.5%)	60 (31.7%)	17 (24.6%)	0.083
Visual acuity better than 20/40	40 (19.2%)	44 (23.3%)	6 (8.7%)	0.032
Visual acuity worse than 20/320	40 (19.2%)	16 (8.5%)	11 (15.9%)	0.009
Submacular hemorrhage criterion	9 (4.3%)	31 (16.4%)	2 (2.9%)	<0.001

Data are presented as number (%).AMD = age-related macular degeneration, PCV = polypoidal choroidal vasculopathy. Statistical analysis was performed using the chi-square test.