The Diagnostic Capability of Swept Source OCT Angiography in Treatment-Naive Exudative Neovascular Age-Related Macular Degeneration

Figure 1

Detection of macular neovascularization (MNV) in age-related macular degeneration (AMD) by fluorescein angiography (FA), indocyanine green angiography (ICGA), and 4.5 × 4.5 mm en-face swept source; optical coherence tomography angiography (SS-OCTA). (A1) Type 1 MNV with speckled hyperfluorescence in FA (A2) ICGA visualized the neovascular lesion (arrow). (A3) Evidence of MNV (arrow) in en-face SS-OCTA with choriocapillaris (CC) segmentation under the retinal pigment epithelium (RPE) but (A4) absence of flow in the outer retina (OR) slab. (B1) Leakage in FA consistent with a type 2 MNV (arrow) in a left eye. (B2) Early ICGA highlighted a well demarcated MNV (arrow). (B3) Automated en-face SS-OCTA CC scan with a dense MNV (arrow) surrounded by a dark halo and projection artifacts of the superficial retinal vessels. (B4) Automated en-face SS-OCTA OR segmentation with the same neovascular complex in an otherwise nonvascularized tissue. (C1) A hyperfluorescent spot (arrow) in early FA and (C2) late ICGA diagnosed as type 3 MNV. (C3) Evidence of a neovascularization in the en-face SS-OCTA with CC and (C4) OR segmentation. (D1) Mixed type MNV with early leakage surrounded by speckled hyperfluorescence in FA (D2) ICGA with a neovascular lesion. (D3) MNV presence (circle) under the RPE in the en-face SS-OCTA CC slab and (D4) clear evidence of MNV over the RPE in the OR segmentation.