The Diagnostic Capability of Swept Source OCT Angiography in Treatment-Naive Exudative Neovascular Age-Related Macular Degeneration

Figure 2

Detection of macular neovascularization (MNV) in age-related macular degeneration (AMD) by fluorescein angiography (FA), indocyanine green angiography (ICGA), and cross-sectional swept source-optical coherence tomography angiography (SS-OCTA). (A1) Early FA with drusen staining and a focal speckled hyperfluorescence (arrow) representing type 1 MNV in a left eye. (A2) Early ICGA with a circumscribed neovascular lesion (arrow) at the same location as shown in FA. (A3) Manual segmentation of a 4.5 × 4.5 mm en-face OCTA CC slab without evidence of a MNV membrane below the retinal pigment epithelium (RPE) besides projection artifacts and signal loss but flow density in color coded cross-sectional SS-OCTA. (A4) Manual segmentation of a 4.5 × 4.5 mm en-face OCTA CC slab across the fovea and cross-sectional SS-OCTA with no flow suspicious of a neovascularization in an otherwise dome-shaped pigment epithelium detachment. (B1) Ill-defined hyperfluorescence and drusen staining in early FA. (B2) ICGA revealed a hypercyanescent nodule consistent with a polypoidal lesion corresponding to (B3) cross-sectional flow density in SS-OCTA CC slab through the point of interest. (B4) 9 × 9 mm en-face OCTA OR slab at the fovea with hollow cystoid spaces besides projection artifacts but no evidence of neovascularization.