Research Article

Efficacy of Topical Hydrocortisone in Combination with Topical Ciclosporin A for the Treatment of Dry Eye Disease in Patients with Sjögren Syndrome

Table 3

Study parameters at baseline and after 2 weeks and 6 months of treatment, separately for the two treatment regimens.

Baseline2 weeks6 months

OSDI56.0 ± 18.242.1 ± 22.00.00228.2 ± 15.5<0.001
Ciclosporin A+hydrocortisone (CsA+Hc)
Visual Analogue Scale39.0 ± 20.626.3 ± 19.4<0.00119.1 ± 17.7<0.001
Tear BUT (sec)2.8 ± 1.34.2 ± 1.30.0085.4 ± 1.30.003
Fluorescein Oxford staining grade3.3 ± 0.52.8 ± 0.70.0251.6 ± 0.70.001
Lissamine Oxford staining grade3.0 ± 0.92.7 ± 0.70.0461.7 ± 0.80.002
Schirmer test (mm/5 min)3.6 ± 1.84.6 ± 1.30.0865.6 ± 1.90.049
MG dropout rate (%)31.9 ± 12.730.6 ± 12.50.094
Corneal MTF0.38 ± 0.110.50 ± 0.220.037
Corneal Strehl ratio0.18 ± 0.130.30 ± 0.280.042
Intraocular pressure14.0 ± 2.014.6 ± 2.00.28914.4 ± 3.10.952

Ciclosporin A (CsA)
Visual Analogue Scale35.9 ± 20.424.6 ± 19.90.00220.9 ± 18.70.001
Tear BUT (sec)3.4 ± 1.63.6 ± 1.60.4935.0 ± 0.90.007
Fluorescein Oxford staining grade3.1 ± 0.32.9 ± 0.70.3171.8 ± 0.90.004
Lissamine Oxford staining grade3.0 ± 0.92.6 ± 0.70.0251.8 ± 0.90.002
Schirmer test (mm/5 min)3.3 ± 1.44.1 ± 1.30.0575.6 ± 2.00.050
MG dropout rate (%)33.2 ± 12.131.8 ± 12.70.070
Corneal MTF0.38 ± 0.150.40 ± 0.160.923
Corneal Strehl ratio0.22 ± 0.210.23 ± 0.210.945
Intraocular pressure (mmHg)14.2 ± 2.714.5 ± 2.00.75714.4 ± 2.80.836

Data are presented as mean ± SD; : difference between baseline and values at 2 weeks and 6 months using t test for paired samples and Wilcoxon signed-rank test. Significant values are indicated in bold.