Prognostic Factors and Nomograms for Overall and Cancer-Specific Survival of Patients with Uveal Melanoma without Metastases: A SEER Analysis of 4119 Cases

Table 2

Univariate Cox regression analysis of OS and CSS in the training group.

	OS		CSS
	HR (95% CI)	value	HR (95% CI)	value
Age, years
≤57	1		1
58–79	2.128 (1.837–2.465)		1.576 (1.326–1.873)
≥80	5.236 (4.380–6.260)		2.005 (1.543–2.605)
Sex		0.050		0.383
Male	1		1
Female	0.888 (0.789–1.000)		0.934 (0.800–1.089)
Race		0.379		0.687
White	1		1
Black	0.607 (0.252–1.461)		0.619 (0.199–1.926)
Other	0.797 (0.470–1.350)		1.078 (0.594–1.957)
Marital status
Married	1		1
Single	1.058 (0.886–1.263)		0.850 (0.668–1.083)
Divorced/separated	1.265 (1.032–1.551)		1.260 (0.977–1.625)
Widowed	2.154 (1.831–2.534)		1.432 (1.129–1.817)
Year of diagnosis		0.577		0.856
2004–2007	1		1
2008–2011	1.033 (0.897–1.189)		1.013 (0.842–1.217)
2012–2015	0.946 (0.805–1.113)		0.956 (0.780–1.172)
Laterality		0.563		0.144
Left	1		1
Right	1.052 (0.935–1.184)		1.115 (0.956–1.302)
Bilateral	1.638 (0.409–6.566)		2.855 (0.711–11.465)
Primary site
Choroid	1		1
Ciliary body	1.232 (1.029–1.476)		1.342 (1.067–1.689)
Iris	0.508 (0.253–1.019)		0.420 (0.157–1.123)
Histological type
Spindle cell	1		1
Epithelioid cell	2.845 (2.027–3.993)		3.851 (2.464–6.018)
Mixed cell	2.442 (1.873–3.185)		3.348 (2.327–4.816)
Other/unknown	1.282 (1.032–1.592)		1.556 (1.139–2.126)
T-stage
T1	1		1
T2	1.573 (1.356–1.825)		1.867 (1.517–2.299)
T3/T4	3.273 (2.788–3.843)		4.622 (3.729–5.728)
Treatment
Surgery only	1		1
Radiation only	0.564 (0.494–0.643)		0.473 (0.399–0.560)
Surgery + radiation	0.717 (0.573–0.897)		0.817 (0.625–1.067)
Sequence number				0.228
Only one	1		1
More	1.494 (1.321–1.689)		0.897 (0.752–1.070)

HR: hazard ratio, CI: confidence interval, OS: overall survival, and CSS: cancer-specific survival. .