Prognostic Factors and Nomograms for Overall and Cancer-Specific Survival of Patients with Uveal Melanoma without Metastases: A SEER Analysis of 4119 Cases

Table 3

Multivariate Cox regression analysis of OS and CSS in the training group.

	OS		CSS
	HR (95% CI)	value	HR (95% CI)	value
Age, years
≤57	1		1
58–79	2.005 (1.723–2.332)		1.501 (1.262–1.785)
≥80	4.384 (3.601–5.339)		1.804 (1.386–2.348)
Marital status		0.004		0.174
Married	1		1
Single	1.189 (0.994–1.423)	0.059	0.853 (0.667–1.090)	0.203
Divorced/separated	1.253 (1.020–1.539)	0.032	1.186 (0.918–1.532)	0.195
Widowed	1.304 (1.095–1.553)		1.142 (0.887–1.470)	0.305
Primary site
Choroid	1		1
Ciliary body	1.135 (0.944–1.366)	0.178	1.244 (0.983–1.573)	0.069
Iris	0.484 (0.240–0.978)		0.437 (0.162–1.175)	0.101
Histological type
Spindle cell	1		1
Epithelioid cell	1.929 (1.367–2.720)		2.740 (1.746–4.299)
Mixed cell	1.971 (1.508–2.576)		2.669 (1.853–3.836)
Other/unknown	1.823 (1.442–2.304)		2.472 (1.770–3.451)
T-stage
T1	1		1
T2	1.567 (1.348–1.822)		1.936 (1.568–2.390)
T3/T4	2.804 (2.379–3.306)		4.096 (3.289–5.100)
Treatment
Surgery only	1		1
Radiation only	0.579 (0.489–0.685)		0.484 (0.391–0.598)
Surgery + radiation	0.743 (0.586–0.943)		0.838 (0.630–1.116)	0.227
Sequence number
Only one	1
More	1.232 (1.087–1.396)

HR: hazard ratio, CI: confidence interval, OS: overall survival, and CSS: cancer-specific survival. .