Analysis of Tear Function Outcomes following Collagen Cross-Linking Treatment in Ectatic Corneas
Table 1
Analysis of parameter changes in the epi-on group during the follow-up period.
Parameter
Preoperative
1 month
3 months
6 months
12 months
BCVA
0.60 ± 0.36 (0.24–0.90)
0.63 ± 0.33 (0.49–0.98)
0.59 ± 0.33 (0.34–1.06)
0.66 ± 0.36 (0.33–1.08)
0.69 ± 0.37 (0.36–1.12)
value
0.436
0.832
0.303
0.090
Kmax (D)
55.75 ± 8.95 (45.83–68.56)
57.46 ± 7.78 (47.70–66.80)
54.89 ± 8.63 (45.43–66.61)
56.40 ± 8.62 (45.89–68.48)
55.52 ± 8.70 (46.02–48.65)
value
0.533
0.028
0.789
0.293
OSDI (score)
11.33 ± 6.10 (8.76–13.91)
10.86 ± 7.74 (6.39–15.33)
10.14 ± 4.78 (8.02–12.26)
8.94 ± 4.45 (6.73–11.16)
10.27 ± 6.72 (5.76–14.79)
value
0839
0.450
0.434
0.908
Tear meniscus height (mm)
0.22 ± 0.05 (0.20–0.25)
0.23 ± 0.06 (0.20–0.26)
0.21 ± 0.07 (0.18–0.24)
0.20 ± 0.04 (0.18–0.22)
0.21 ± 0.06 (0.18–0.24)
value
0.630
0.694
0.151
0.240
1st NIKBUT (s)
6.62 ± 3.65 (4.86–8.39)
6.43 ± 4.06 (3.98–8.89)
7.25 ± 4.33 (5.02–9.48)
8.16 ± 6.57 (4.90–11.43)
11.14 ± 7.64 (6.28–15.99)
value
0.181
0.164
0.067
0.001
Average NIKBUT (s)
11.42 ± 5.93 (8.56–14.28)
10.87 ± 6.11 (7.18–14.57)
11.75 ± 5.32 (9.02–14.48)
11.53 ± 7.02 (8.03–15.02)
13.30 ± 7.61 (8.47–18.14)
value
0.021
0.971
0.637
0.146
Bulbar redness (score)
1.03 ± 0.41 (0.86–1.21)
1.13 ± 0.46 (0.88–1.37)
1.05 ± 0.43 (0.85–1.24)
0.98 ± 0.39 (0.81–1.16)
1.01 ± 0.34 (0.81–1.21)
value
0.549
0.711
0.289
0.426
BCVA: Best-corrected visual acuity (decimal visual acuity style); Kmax: maximum keratometry; OSDI: ocular surface disease index; NIKBUT: Noninvasive Keratograph breakup time; SD: standard deviation. value means that the test level has a statistical difference at 0.05, and value means that the test level has a statistical difference at 0.01. “()” means 95% CI (CI is confidence interval).
