Analysis of Tear Function Outcomes following Collagen Cross-Linking Treatment in Ectatic Corneas
Table 2
Analysis of parameter changes in the epi-off group during the follow-up period.
Parameter
Preoperative
1 month
3 months
6 months
12 months
BCVA
0.64 ± 0.31 (0.29–0.86)
0.67 ± 0.30 (0.40–0.94)
0.67 ± 0.28 (0.45–0.95)
0.69 ± 0.29 (0.46–0.97)
0.69 ± 0.28 (0.45–0.95)
value
0.111
0.107
0.290
0.111
Kmax (D)
54.85 ± 6.22 (50.71–63.26)
55.83 ± 6.14 (52.24–63.85)
54.05 ± 6.07 (50.55–61.37)
53.65 ± 5.38 (50.41–61.22)
53.95 ± 6.00 (50.39–63.04)
value
0.294
0.306
0.048
0.105
OSDI
11.10 ± 7.19 (8.42–13.78)
9.39 ± 7.41 (6.19–12.60)
9.53 ± 9.22 (5.08–13.97)
9.96 ± 6.75 (7.04–12.88)
10.20 ± 6.92 (6.37–14.03)
value
0.515
0.195
0.336
0.048
Tear meniscus height (mm)
0.21 ± 0.05 (0.19–0.23)
0.21 ± 0.06 (0.19–0.24)
0.21 ± 0.07 (0.19–0.24)
0.22 ± 0.07 (0.19–0.25)
0.22 ± 0.09 (0.17–0.27)
value
0.631
0.810
0.331
0.837
1st NIKBUT (s)
7.71 ± 5.59 (5.29–10.13)
7.17 ± 4.49 (5.12–9.21)
8.73 ± 6.43 (5.72–11.74)
7.05 ± 4.95 (4.50–9.59)
9.98 ± 7.75 (5.05–14.90)
value
0.939
0.953
0.726
0.099
Average NIKBUT (s)
10.09 ± 5.36 (7.77–12.40)
11.06 ± 5.86 (8.39–13.73)
11.77 ± 6.62 (8.67–14.86)
10.81 ± 5.73 (7.86–13.75)
14.43 ± 7.81 (9.47–19.39)
value
0.091
0.232
0.206
<0.01
Bulbar Redness (score)
1.01 ± 0.36 (0.88–1.14)
0.91 ± 0.37 (0.77–1.06)
0.87 ± 0.44 (0.69–1.05)
0.89 ± 0.37 (0.73–1.06)
0.81 ± 0.29 (0.65–0.97)
value
0.569
0.556
0.230
0.001
BCVA: Best-corrected visual acuity (decimal visual acuity style); Kmax: maximum keratometry; OSDI: ocular surface disease index; NIKBUT: Noninvasive Keratograph breakup time; SD: standard deviation. value means that the test level has a statistical difference at 0.05, and value means that the test level has a statistical difference at 0.01. “()” means 95% CI (CI is confidence interval).
