Research Article

Analysis of Tear Function Outcomes following Collagen Cross-Linking Treatment in Ectatic Corneas

Table 3

Analysis of parameter changes between the two groups.

VariableGroupΔ1 Month mean ± SDΔ3 Months mean ± SDΔ6 Months mean ± SDΔ12 Months mean ± SD

BCVAEpi-on0.02 ± 0.49 (−0.12–0.45)−0.01 ± 0.49 (−0.13–0.40)0.06 ± 0.51 (−0.11–0.38)0.09 ± 0.52 (−0.04–0.37)
Epi-off0.04 ± 0.44 (−0.04–0.24)0.04 ± 0.42 (−0.05–0.31)0.05 ± 0.43 (−0.03–0.32)0.05 ± 0.42 (−0.04–0.29)
value0.6520.5250.8990.767
Kmax (D)Epi-on1.71 ± 11.89 (−2.74–2.84)−0.86 ± 12.43 (−2.39–0.02)0.65 ± 12.43 (−0.45–0.42)−0.24 ± 12.49 (−0.29–0.56)
Epi-off0.98 ± 8.74 (−0.19–2.30)−0.80 ± 8.69 (−3.19–1.00)−1.20 ± 8.21 (−2.97–0.62)−0.91 ± 8.64 (−1.57–1.03)
value0.5760.8180.2130.406
OSDI (score)Epi-on−0.48 ± 9.91 (−3.74–5.46)−1.20 ± 7.68 (−4.93–1.57)−2.39 ± 7.43 (−6.07–0.85)−1.06 ± 9.15 (−4.00–3.09)
Epi-off−1.71 ± 10.46 (6.64–0.57)−1.57 ± 12.01 (−8.05–0.26)−1.14 ± 9.87 (−1.58–2.27)−0.90 ± 9.99 (−2.55–1.88)
value0.1120.1070.2540.896
Tear meniscus height (mm)Epi-on0.01 ± 0.08 (−0.01–0.05)−0.01 ± 0.09 (−0.05–0.02)−0.02 ± 0.07 (−0.04–0.00)−0.01 ± 0.08 (−0.05–0.03)
Epi-off0.00 ± 0.08 (−0.02–0.02)0.01 ± 0.08 (−0.02–0.02)0.02 ± 0.09 (−0.01–0.04)0.01 ± 0.10 (−0.03–0.05)
value0.2260.2080.0360.615
1st NIKBUT (s)Epi-on−0.19 ± 5.47 (−3.22–2.54)0.62 ± 5.64 (−1.67–2.98)1.54 ± 7.21 (−1.87–5.57)4.51 ± 7.82 (2.07–9.39)
Epi-off−0.55 ± 7.13 (−4.26–2.81)1.02 ± 8.50 (−3.38–5.31)−0.67 ± 7.45 (−4.95–3.05)2.26 ± 9.40 (−1.64–3.85)
value0.9720.9760.4880.066
Average NIKBUT (s)Epi-on−0.55 ± 8.53 (−5.17–2.29)0.32 ± 7.98 (−2.48–2.68)0.10 ± 9.19 (−3.58–4.35)1.88 ± 9.55 (0.35–8.27)
Epi-off0.97 ± 7.93 (−2.32–3.94)1.68 ± 8.45 (−2.14–6.38)0.72 ± 7.83 (−4.25–4.62)4.34 ± 9.30 (−1.51–7.09)
value0.3570.3451.0000.759
Bulbar redness (score)Epi-on0.09 ± 0.61 (−0.09–0.19)0.01 ± 0.59 (−0.04–0.20)−0.05 ± 0.57 (−0.28–0.09)−0.02 ± 0.53 (−0.24–0.24)
Epi-off−0.09 ± 0.52(−0.21–0.10)−0.14 ± 0.58 (−0.26–0.05)−0.12 ± 0.52 (−0.34–0.04)−0.20 ± 0.46 (−0.63–0.12)
value0.7210.0210.6280.062

BCVA: Best-corrected visual acuity (decimal visual acuity style); Kmax: maximum keratometry; OSDI: ocular surface disease index; NIKBUT: Noninvasive Keratograph breakup time; SD: standard deviation. “Δ” means the difference between pre- and postoperative values.