Characteristics of Optic Neuritis in South Korean Children and Adolescents: A Retrospective Multicenter Study
Table 3
Comparison of patient demographics and clinical characteristics of pediatric optic neuritis.
Variable
Pineles et al. (n = 44) USA
Wan et al. (n = 46) USA
Averseng-peaureaux et al. (n = 102) France
Ambika et al. (n = 78) India
Chen et al. (n = 59) China
Present study (n = 127) Korea
Age, years (range)
10.2 (3.9–13.5)
12.6 (3.9–18.ct8)
11†
11.8 (2–18)
12.3 (5–18)
10.7 (3.6–18.6)
Gender (female), %
41%
72%
66%
54%
69%
62%
Pain with eye movement
—
43%
49%
46%
83%
47%
Bilateral involvement
36%
41%
37%
50%
63%
42%
Optic disc swelling
75%
67%
52%
50%
64%
67%
Severe visual loss at presentation (<20/200)
52%
50%
48%
NA
45%
66%
Final visual outcome
≥20/40
85%
90%
72%‡
71%
85%
76%
<20/40-≥ 20/200
11%
8%
NA
NA
4%
15%
<20/200
4%
3%
NA
NA
11%
9%
Final diagnosis
Isolated ON
48%
48%
58%
89%
69%
48%
Recurrent ON
18% (MOGAD)
—
6%
—
10%
12%
MS
11%
39%
21%
6%
3%
19%
NMOSD
7%
7%
5%
—
15%
13%
ADEM-ON
16%
7%
—
5%
3%
8%
ADEM = acute disseminated encephalomyelitis; NMOSD = neuromyelitis optica spectrum disorder; MOGAD = myelin oligodendrocyte glycoprotein-associated disorder; MS = multiple sclerosis; ON = optic neuritis. †The age in this study was presented as median. ‡72% of the patients had complete visual recovery (complete visual recovery defined as the recovery of normal visual acuity (20/20), or prior visual acuity if it was abnormal before optic neuritis occurrence).
