Comparative Study of Conventional Inverted ILM Flap Covering and ILM Flap Filling Technique in Idiopathic Macular Hole Treatment: A Meta-Analysis and Systematic Review

Table 1

Demographic characteristics and ophthalmic information of the included studies.

Study

Country

Study design

Group

No. eyes

Age (years)

Gender (male and female)

Duration of MH (months)

Minimum diameter of MH (μm)

Staining

Endotamponade

MH closure rate (%)

Pre-BCVA (logMAR)

Post-BCVA (logMAR)

Follow-up time (months)

Rossi [15]

Italy

RCT

Covering

13

71.3 ± 9.2

5.8

<6

553 ± 164

BBG

20% SF6

84.6

1.17 ± 0.24

0.58 ± 0.39

3

Filling

13

67.7 ± 7.3

6.7

<6

555 ± 153

BBG

20% SF6

100

1.37 ± 0.37

0.58 ± 0.42

3

Park [17]

South Korea

Retrospective

Covering

26

65.7 ± 7.2

3.23

7.1 ± 5.2

662 ± 121

BBG

18% SF6

100

1.20 ± 0.40

0.53 ± 0.20

6

Filling

15

66.3 ± 7.8

6.9

4.1 ± 5.1

657 ± 122

BBG

18% SF6

100

1.00 ± 0.30

0.77 ± 0.30

6

Cacciamani [8]

Italy

RCT

Covering

14

N/A

7.7

<6

N/A

BBG

20% SF6

100

0.84 ± 0.32

0.79 ± 0.36

3

Filling

14

N/A

5.9

<6

N/A

BBG

20% SF6

100

0.18 ± 0.12

0.23 ± 0.16

3

Faria [23]

Portugal

Retrospective

Covering

38

N/A

19.19

N/A

N/A

Brilliant peel dual

15% SF6

100

N/A

N/A

12

Filling

24

N/A

16.8

N/A

N/A

Brilliant peel dual

15% SF6

100

N/A

N/A

12

Iwasaki [9]

Japan

Retrospective

Covering

13

64.3 ± 16.6

5.8

N/A

609 ± 111

BBG and TA

20% SF6

100

0.98 ± 0.30

0.61 ± 0.38

10.9 ± 4.1

Filling

12

62.7 ± 17.9

3.9

N/A

582 ± 129

BBG and TA

20% SF6

100

0.73 ± 0.23

0.55 ± 0.32

16.2 ± 8.4

Yamada [24]

Japan

Retrospective

Covering

5

N/A

N/A

N/A

<400

N/A

SF6

80

N/A

N/A

12

Filling

16

N/A

N/A

N/A

<400

N/A

SF6

93.8

N/A

N/A

12

Xiong [16]

China

Retrospective

Covering

30

64.2 ± 7.6

10.20

6.92 ± 11.41

1217 ± 186 (baseline)

ICG

Air

96.7

1.13 ± 0.32

0.77 ± 0.26

1

Filling

27

66.6 ± 6.3

4.22

6.92 ± 11.41

1305 ± 188 (baseline)

ICG

Air

100

1.19 ± 0.39

0.92 ± 0.24

1

Data were converted into the form of statistical mean ± standard deviation as far as possible. MH = macular hole, Pre-BCVA = preoperative best-corrected visual acuity, post-BCVA = postoperative best-corrected visual acuity, LogMAR = the logarithm of the minimal angle of resolution, RCT = randomized controlled trial, BBG = brilliant blue G, TA = triamcinolone acetonide, ICG = indocyanine green, SF6 = sulphur hexafluoride, and N/A = not available for statistics.