Evaluation of Neurodevelopmental Outcomes in Premature Twins (Multigestations) with Retinopathy of Prematurity Receiving Anti-VEGF: A Comparison Study

Table 5

Neurodevelopment milestones between IVB treated versus laser treated preamature multigestation neonates.

	Type treatment		Diff	95% CI		value
	IVB	Laser		Lower	Upper
Head up	5 ± 2.6	4.6 ± 1.2	0.364	−0.621	1.348	0.469
Laughing	3 ± 1.1	3 ± 1.1	−1.17E − 17	−0.308	0.308	1.000
Sit head steady	9.9 ± 5.4	8 ± 2.1	1.909	−0.775	4.593	0.163
Regard own hand	4.4 ± 1.7	4.1 ± 1.4	0.25	−0.05	0.55	0.102
Rollover	4.9 ± 1.4	4.6 ± 1	0.273	−0.237	0.782	0.294
Grasp rattle	5.6 ± 3.9	4.4 ± 0.8	1.223	−0.692	3.138	0.211
Sit no support	10 ± 2.6	9.1 ± 2.5	0.909	−0.258	2.076	0.127
Turn to voice	4.9 ± 3.1	5 ± 3.1	0.125	−0.29	0.54	0.555
Feed self	13.6 ± 6.9	13.5 ± 6.9	0.1	−0.086	0.286	0.292
Reach for toy	6.6 ± 2.5	6.9 ± 2.5	−0.333	−0.641	−0.025	0.034
Stand holding on	13.3 ± 8.3	11.5 ± 3.7	1.727	−1.968	5.423	0.360
Pass cube	8.5 ± 4.8	7.6 ± 3.8	0.818	−0.924	2.561	0.357
Sit alone	17.6 ± 10.4	14.5 ± 2.8	3.126	−2.291	8.543	0.258
Pull to stand	14.4 ± 12.1	11.2 ± 3	3.2	−2.966	9.366	0.309
Bangs 2cubes held in hand	11.3 ± 5.6	9.8 ± 2.8	1.556	−0.891	4.002	0.213
Imitate speech sounds	9.9 ± 6.1	12.2 ± 12.8	−2.3	−11.23	6.63	0.614
Single syllables	13.1 ± 4.1	13.4 ± 7.1	−0.65	−3.672	2.372	0.673
Wave bye-bye	15 ± 6.8	14.5 ± 5.6	0.455	0.431	1.341	0.315
Imitate activities	14.6 ± 3.3	14.2 ± 3.3	0.333	−0.777	1.444	0.556
Walk well	20.9 ± 10.8	17.5 ± 4.9	3.4	−2.94	9.74	0.293
Stoop and recover	17.7 ± 8.7	15.5 ± 3.6	2.273	−2.367	6.913	0.337
Scribble	21.4 ± 8	21.7 ± 8.3	−0.222	−0.494	0.049	0.109
Put block in cup	17 ± 8.1	16 ± 6.5	1	−3.928	5.928	0.691
Drink from cup	19.2 ± 7.1	19.8 ± 9.5	−0.636	−4.485	3.212	0.746
Runs	23 ± 7.9	23 ± 6.7	−0.333	−1.022	0.355	0.343
Walk backwards	25.7 ± 1.5	26.6 ± 4.1	−0.285	5.514	4.944	0.915
Remove garment	31.1 ± 10.2	30.5 ± 11.4	0.545	−4.343	5.434	0.827
Help in house	35.4 ± 14	37.6 ± 14.7	−0.857	−2.413	0.698	0.280
Walk up steps	24 ± 6.4	25 ± 6.9	−1.099	−3.423	1.225	0.354
Kick ball	27.5 ± 12	26.3 ± 10.1	1.2	−4.006	6.406	0.651
Put on clothing	35.1 ± 12.8	34 ± 12.1	1.091	−2.556	4.738	0.558
Name pictures	27.2 ± 16.9	26.5 ± 15.5	0.727	−4.3	5.755	0.777
Jump up	40.1 ± 12	38.9 ± 12.9	−0.857	−2.412	0.698	0.280
Balance each foot	40.4 ± 17	39 ± 16.3	0	0	0	0.350
Brush teeth with help	42.9 ± 13.4	42.3 ± 14.1	6.39E − 05	−9.21E − 05	0	0.422
Speech all understandable	30.6 ± 14.5	33.4 ± 14.4	−2.5	−6.585	1.585	0.230