Relationship of Retinal Vessel Caliber with Age-Related Macular Degeneration

Table 4

Retinal vascular parameters associated with AMD progression after 5 years.

Factor	Category/increment	Change in AMD severity score (n = 820)			Progression to CNV (n = 95)			Progression to CGA (n = 64)
		B	95% CI	value	B	95% CI	value	B	95% CI	value
Age	1 year	0.005	−0.013, 0.023	0.574	0.058	0.008, 0.108	0.023	0.056	−0.008, 0.120	0.087
Sex	Female vs. male	−0.053	−0.201, 0.095	0.486	0.116	−0.288, 0.521	0.573	0.019	−0.439, 0.477	0.935
Smoking status	Never	Ref			Ref			Ref
	Former	0.138	−0.044, 0.319	0.137	0.344	−0.128, 0.816	0.154	0.175	−0.440, 0.790	0.577
	Current	0.289	−0.044, 0.622	0.089	0.558	−0.202, 1.319	0.150	0.962	0.114, 1.811	0.026
Cilioretinal artery	Present vs. absent	−0.089	−0.272, 0.094	0.339	−0.157	−0.684, 0.370	0.370	−0.083	−0.730, 0.563	0.801
CRAE	1 mm	0.001	−0.003, 0.006	0.527	−0.007	−0.019, 0.006	0.280	−0.002	−0.019, 0.015	0.795
CRVE	1 mm	0.003	−0.002, 0.007	0.288	−0.003	−0.016, 0.010	0.685	0.004	−0.011, 0.020	0.576
AVR	—	0.049	−1.409, 1.506	0.948	−2.350	−6.443, 1.742	0.260	−1.991	−7.799, 3.817	0.502

AMD, age-related macular degeneration; CNV, choroidal neovascularization; CGA, central geographic atrophy; B, beta coefficient; CI, confidence interval; CRAE, central retinal arteriolar equivalent; CRVE, central retinal venular equivalent; AVR, arteriole-to-venule ratio.