Research Article

Effects of Customized Progressive Addition Lenses vs. Single Vision Lenses on Myopia Progression in Children with Esophoria: A Randomized Clinical Trial

Table 2

Adjusted 2-year myopia progression and mean difference between study groups defined by baseline characteristics.

Baseline characteristicsPAL groupSVL groupDifference ± SE£ (D)Simultaneous 95% CI
nAddition lenses# (D)Mean ± SE (D)nMean ± SE (D)

Gender
 Male191.76 ± 0.11−1.21 ± 0.1519−1.40 ± 0.150.19 ± 0.11(−0.04 to 0.42)
 Female251.71 ± 0.10−1.42 ± 0.1321−1.67 ± 0.140.25 ± 0.14(−0.03 to 0.53)

Myopic parent$
 Without201.81 ± 0.12−0.92 ± 0.1417−1.39 ± 0.160.47 ± 0.15(0.18 to 0.76)†
 With241.67 ± 0.13−1.65 ± 0.1323−1.67 ± 0.140.02 ± 0.17(−0.29 to 0.33)

Age (years)
 7∼11201.69 ± 0.12−1.45 ± 0.1316−1.67 ± 0.190.22 ± 0.13(−0.07 to 0.52)
 11∼14241.77 ± 0.11−1.21 ± 0.1424−1.47 ± 0.130.26 ± 0.10(−0.08 to 0.61)

Baseline accommodative lag to 3 D demand (D)$
 Low (<1.00)231.64 ± 0.09−1.33 ± 0.1520−1.43 ± 0.140.10 ± 0.16(−0.25 to 0.44)
 High (≥1.00)211.82 ± 0.14−1.31 ± 0.1420−1.67 ± 0.150.36 ± 0.11(0.12 to 0.60)†

Baseline near phoria (33 cm)
2< esophoria ≤6161.57 ± 0.11−1.34 ± 0.1722−1.50 ± 0.140.16 ± 0.11(−0.13 to 0.55)
 esophoria >6281.82 ± 0.13−1.31 ± 0.1118−1.61 ± 0.170.30 ± 0.10(0.12 to 0.48)†

Baseline cycloplegic autorefraction (D)$
 Less myopia (>−2.00)261.68 ± 0.08−1.14 ± 0.1224−1.47 ± 0.130.33 ± 0.09(0.14 to 0.52)†
 More myopia (≤−2.00)181.80 ± 0.13−1.58 ± 0.1516−1.67 ± 0.170.09 ± 0.12(−0.15 to 0.33)
Overall441.73 ± 0.07−1.32 ± 0.0840−1.55 ± 0.090.23 ± 0.08(0.04 to 0.42)†

SER <−0.75 D, determined by noncycloplegic autorefraction; £PAL-SVL; significant treatment effect (); $significant interaction (); #addition lenses were analyzed among the prescriptions of all time points.