Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

Table 4

Effects of ovariectomy (Ovx) and three doses of vitamin E: low dose (LD, 300 mg/kg diet), medium dose (MD, 525 mg/kg diet), and high dose (HD, 750 mg/kg diet) on three-dimensional (3D) microcomputed tomography (μCT) structural parameters of fifth lumbar vertebrae.

Parameters	Sham	Ovx	LD	MD	HD
BV/TV (%)	0.382±0.023^a	0.242±0.023^b	0.208±0.023^b	0.217±0.023^b	0.230±0.023^b
Tb.N (1/mm)	3.290±0.150^a	2.920±0.150^ab	2.660±0.150^b	2.560±0.150^b	2.900±0.150^ab
Tb.Th (mcm)	0.109±0.003^a	0.087±0.003^b	0.084±0.003^b	0.088±0.003^b	0.084±0.003^b
Tb.Sp (mcm)	0.295±0.018^a	0.339±0.018^ab	0.378±0.018^b	0.387±0.018^b	0.345±0.018^ab
Conn.D (1/mm^3)	25.8±2.5^a	33.4±2.5^b	29.5±2.5^ab	25.3±2.5^a	34.1±2.5^b
SMI	1.158±0.258^a	0.295±0.258^b	0.640±0.258^b	0.472±0.258^b	0.427±0.258^b

Values within a row that share the same superscript letters are not significantly (𝑃≥.05) different. Values are means ± S.E.M.
BV/TV: bone volume as percentage of tissue volume; Tb.Th: trabecular thickness; Tb.N: trabecular number; Tb.Sp: trabecular separation; Conn.D: connective density; SMI: structure model index.