Differential Gene Expression Analysis of Placentas with Increased Vascular Resistance and Pre-Eclampsia Using Whole-Genome Microarrays

Figure 3

Pathophysiology. Based on the gene expression results, we suggest that there may be a placental mechanism that determines how PE progresses from stage one, characterized by inadequate perfusion of the placenta, to the clinical symptoms in stage two. Depending on which inflammatory genes that are expressed, the placenta may either progress from a state of notch to early onset PE or remain clinically asymptomatic only showing signs of bilateral notch.